Hilde Schjerven, Ph.D., is an academic scientist in the field
of molecular biology with a strong focus on transcriptional
regulation in the immune system.
The Ph.D. thesis work of Dr. Schjerven was in the area of
Mucosal Immunology under the mentors Dr.
Per Brandtzaeg and Dr.
Finn-Eirik Johansen at University of Oslo, Norway. The
research focused on the cytokine-induced transcriptional
regulation of the gene encoding the human polymeric
Immunoglobulin Receptor (pIgR), also known as Secretory
Component (SC). pIgR is expressed by mucosal epithelial cells
and is required to transport antibodies (IgA and IgM) into the
secretions as secretory antibodies.
Dr. Schjerven then moved to the University of California, Los
USA) to perform postdoctoral research on gene regulation in
the immune system with Dr.
Stephen T. Smale. The project developed to focus on the
mechanism of action for Ikaros, a transcription factor
critical for the proper development of the immune system. Dr.
Schjerven continued working on this research project at UCLA
as a Scientist.
Next, Dr. Schjerven worked with Dr.
Markus Muschen, initially at Children's Hospital Los
USA), then relocated to University of California, San
USA), to continue studies on the role of Ikaros as a critical
tumor suppressor in Acute Lymphoblastic Leukemia (ALL).
Currently, Dr. Schjerven is an Assistant
Professor in Department
of Laboratory Medicine at UCSF. The overall interest of
her research group is to
study transcriptional regulation of hematopoietic development
and function, as well as how deregulation of key transcription
factors can lead to disease, such as malignant transformation
(leukemia). The main focus of the current work is on the
transcription factor Ikaros, encoded by the Ikzf1
gene, and to elucidate the mechanism by which this factor
controls both hematopoietic development and disease, in
particular in the lymphoid lineage.
Please feel free to contact Dr.
Schjerven, if you have any questions or comments in
regards to this website, or the content presented herein.
5/13-5/17-2016: AAI Immunology 2016 meeting in Seattle, WA
12/13-2013: Dept. of Lab. Medicine, UCSF and Leukemia
interest group joint lab meeting, San Francisco, UCSF, USA
5/24-2012: ImmunologyLA 2012 - Los Angeles, USA
5/7-2012: Immunology 2012 - American Association of
Annual Meeting. Boston, USA (May 4th - 8th, 2012)
April, 2010: Guest Lecture, Norwegian Society of Immunology (NSI), Oslo, Norway
Nov, 2009: Selected talk at "Mechanisms of Early
Lymphocyte Development Symposium", organized by Abcam. San