Background

Hilde Schjerven, Ph.D., is an academic scientist in the field of molecular biology with a strong focus on transcriptional regulation in the immune system.

The Ph.D. thesis work of Dr. Schjerven was in the area of Mucosal Immunology under the mentors Dr. Per Brandtzaeg and Dr. Finn-Eirik Johansen at University of Oslo, Norway. The research focused on the cytokine-induced transcriptional regulation of the gene encoding the human polymeric Immunoglobulin Receptor (pIgR), also known as Secretory Component (SC). pIgR is expressed by mucosal epithelial cells and is required to transport antibodies (IgA and IgM) into the secretions as secretory antibodies.

Dr. Schjerven then moved to the University of California, Los Angeles (UCLA, USA) to perform postdoctoral research on gene regulation in the immune system with Dr. Stephen T. Smale. The project developed to focus on the mechanism of action for Ikaros, a transcription factor critical for the proper development of the immune system. Dr. Schjerven continued working on this research project at UCLA as a Scientist.

Next, Dr. Schjerven worked with Dr. Markus Muschen, initially at Children's Hospital Los Angeles (CHLA, USA), then relocated to University of California, San Francisco (UCSF, USA), to continue studies on the role of Ikaros as a critical tumor suppressor in Acute Lymphoblastic Leukemia (ALL).

Currently, Dr. Schjerven is an Assistant Professor in Department of Laboratory Medicine at UCSF. The overall interest of her research group is to study transcriptional regulation of hematopoietic development and function, as well as how deregulation of key transcription factors can lead to disease, such as malignant transformation (leukemia). The main focus of the current work is on the transcription factor Ikaros, encoded by the Ikzf1 gene, and to elucidate the mechanism by which this factor controls both hematopoietic development and disease, in particular in the lymphoid lineage.

Please feel free to contact Dr. Schjerven, if you have any questions or comments in regards to this website, or the content presented herein.

Scientific Publications

See Hilde Schjerven's scientific publications listed in PubMed, goto ResearcherID (I-1437-2013) ( see "badge" below), check Orcid profile, Scopus record, or see Publications listed here.

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